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Horizon®

An Epidemiological & Prescriber-based approach to Portfolio Management, Clinical Development, Marketing, Salesforce Optimization & Targeting.

Horizon offers unique data on doctor’s consultation rates in the precise disease areas that a company is targeting. This comprehensive data brings value to departments throughout the company and offers a rational approach to many decisions that have been made by intuition in the past.

The project is based on consultations and patients data for the field survey and on a profit improvement methodology for the analysis.

Horizon Ten Years Benefits

Horizon is an integrated technology, with many potential applications, SOME of them we summarize herewith.

Horizon is based on prescribers / patients PRIMARY data that Bouée collects for ONE given client, to serve this client’s SPECIFIC strategy.

In one country or in a group of countries, Horizon prerequisites are: [a] all of the CLIENT’S EXISTING & FUTURE INDICATIONS (new drugs & lines extensions), as supplied by the client,
[b] PRESCRIBERS’ DEMOGRAPHICS (current data & foreseen evolutions along specialities, sex, ages, type of practices, geographic distribution, etc.), as supplied by Bouée.

Horizon-Macro-Benefits

[Benefit 1] EPIDEMIOLOGIES, for each indication or group of indications surveyed; i.e. numbers of out-consultations, of in-patients, and their foreseen evolutions; also, in which practices (hospitals, clinics, etc.) and by which prescribers (specialities, etc.) are these patients taken care; and, in case of hospitalization, durations of hospitalizations per type of hospitals.

• Horizon uncovers ALL PATIENTS CASES, irrespective of medical practices, reimbursement schemes, vacuity of current pharmacological treatments, etc.
• Large indications such as “hypertension” or “respiratory infections” embody many different types of patients, conditions, etc. Specifying the exact type(s) and condition(s) allows Horizon to precisely describe the corresponding patients’ population(s), as well as the prescribers involved in caring for this(these) exact type(s) and condition(s).

[Benefit 2] INDICATIONS CORRELATIONS & OVERLAPS; i.e. which of the indications surveyed are likely or unlikely to be seen by the same prescribers.

[Benefit 3] HIGH-PRESCRIBERS POPULATIONS: for each indication or group of indications surveyed, for out-consultations or for in-patients, Horizon depicts the MINIMAL numbers of prescribers to target for reaching 60%, 70%, 80%, etc., of the total number of patients. Horizon also depicts the profiles of these selected higher prescribers.

[Benefit 4] (per indication or per group of indications and with the help of an additional input from the client), DETAILING EFFORT WHICH OPTIMIZES PROFIT (also depicts the resulting sales level).

• Given an indication or a group of indications, Horizon determines the maximal percentage of patients our client can primarily reach along an economically viable detailing of the high-prescribers.

In the above-listed [Benefit] extracts, diseases as a main or as a complication can be addressed separately or concomitantly. Hospitals or Clinics can be covered separately or concomitantly. Etc.

In short, Horizon-Macro-Benefits provide needed key-data for PORTFOLIO REVIEW & for SALESFORCE OPTIMIZATION:

• Clinical Strategic Directions Phases I-II-III
• Licensing-in & -out
• Assessment of Mergers Benefits & Threats
• Franchises & Profit Optimization
• Salesforce Optimal Structure.
Etc.

Horizon-Micro-Targeting-Benefits

Horizon evaluates ALL prescribers a client can propose. It means that, FOR EACH indication or group of indications surveyed, Horizon estimates HOW MANY OUT-CONSULTATIONS OR IN-PATIENTS a given prescriber is expected to have.

• For a set pipeline of products, and an established list of prescribers, Horizon allows a Company to instantly assess its current micro-targeting achievements, versus ideal:
  [a] Which prescribers are accurately visited ?
  [b] Which prescribers are inaccurately visited ?
  [c] Which additional prescribers should be targeted ?
• The client’s medical representatives (MRs) can electronically access these prescribers key-data. (Horizon-Index)
• Furthermore, Bouée daily integrates the prescribers' field information that MRs transfer back, and returns actionable guidances to each MR.

Horizon-Additional-Benefits

Horizon as an integrated tool can also generate optional additional data that might be valuable for Marketing, Clinical, or Business purposes, e.g.:

PENETRATIONS: for each indication or group of indications surveyed, Horizon can analyze the client’s out-consultations-penetration, or in-patients-penetration (per type of institutions, locations, etc.), versus the competitors’ penetrations, in THE VERY SEGMENT (type(s) of patients, disease condition(s), and relevant high-prescribers to serve) the client is targeting.

• By cross-reference to other existing data, such as competitive calls data, Horizon can assess the client competitive detailing efficiency, etc.

FOCUS MARKET RESEARCH; as Horizon generates, for each indication or group of indications surveyed, a statistically representative sample (names, addresses,etc.) of high-prescribers, Horizon allows to focus a further collect of market information on - and only on - the high-prescribers the client wants to serve. Learn more...

CLINICAL DEVELOPMENT, (for a given - existing or new - indication or list of indications, in a given territory):

• How many patients there are ?
• Where & By Whom are these patients diagnosed and care for ?
• Clinical Investigators Optimal Coverage ?
• Investigators Pre-Screening.
Etc.

Horizon Process

PREREQUISITES Ten years prescribers modeling Current franchises => Diseases covered NCES & lines extensions => Diseases to be covered

PROCESS & ANALYSIS Epidemiological survey Sample representative of all prescribers Extrapolate current & future epidemiologies Patients <=> Prescribers High-prescribers demographics Patients distribution

Horizon further opportunities

CLINICAL DEVELOPMENT

Patients' demographics

• Investigators templates resulting in better / quicker
  • Investigators enrollment
  • Patients enrollment

FOCUS MARKETING

Per franchise

• Draw of High-prescribers representative samples
• Sales Audit
• High-prescribers penetration (client / competition)
• Product entry monitoring (client / competition)
• Focus market research

FOCUS SALES

High-prescribers search (names / addresses)

High-prescribers Horizon advocates

Identify & motivate salesforce advocates

• Franchises specialization
• Patients / High-prescribers focus
• Calls prerequisites
• Alternative promotions / services
• Representative skills

Note: until we have a mutually agreed and honored contract with our client or prospect on the concerned topic, our Documents, Research Proposals and the relevant Research Procedures are the sole property of Bouée Research Institute & L207. They cannot be used, directly or indirectly, partly or as a whole, without the prior written consent of an authorized person from Bouée Research Institute or L207